How does diabetes get treated
If my blood glucose level is high, what will happen?
Hyperglycemia
is a condition in which your blood sugar levels are too high. A hyperglycemic
state is a glucose level in the blood that is greater than 125 mg/dL when the
person is fasting (no food or drink for at least eight hours).
or a glucose
level in the blood that is higher than 180 mg/dL within one to two hours of
eating
How does
diabetes get treated?
The type of
diabetes you have, how well you manage your blood glucose levels, and any other
health conditions you have are all factors in diabetes treatment.
Diabetes
mellitus: You are
required to take insulin every day if you have this type. Insulin is no longer
produced by your pancreas.
Diabetes
mellitus: Treatments
for this type of diabetes can include insulin, medications (for both diabetes
and conditions that are risk factors for diabetes), and changes to one's
lifestyle, such as eating healthier foods, exercising more, and losing weight.
Prediabetes: The objective is to prevent you from
developing diabetes if you have prediabetes. Treatments focus on risk factors
that can be treated, like losing weight by exercising for at least 30 minutes
five days a week and eating a healthy diet like the Mediterranean diet. As can
be seen in the prevention section of this article, many of the methods used to
prevent diabetes are also used to treat it.
Diabetes
at birth: If you
have this type and your glucose level isn't too high, changing your diet and
getting regular exercise might be your first course of treatment. Your
healthcare team may start you on insulin or medication if your glucose level is
extremely high or the target goal is still not met.
Diabetes
can be treated in one of the following ways with oral medications and insulin:
stimulates
insulin production and release in your pancreas. Slows down the liver's release
of glucose (the liver stores extra glucose).
Blocks the
breakdown of carbohydrates in your stomach or intestines, thereby making your
tissues more insulin-responsive.
enables you
to eliminate glucose from your body through increased urination.
Which
diabetes medications can be taken orally?
The Food and
Drug Administration has granted approval to over 40 diabetes medications. To
discuss all of these drugs is beyond the scope of this article. Instead, we'll
talk about the most common drug classes, how they work, and the names of a few
drugs in each one. If you are a good candidate for medication, your healthcare
team will decide. If that is the case, they will select the best diabetes medication.
The
following drug classes treat diabetes:
Sulfonylureas:
By increasing insulin production in the pancreas, these medications lower blood
glucose levels. Glyburide (Micronase®, DiaBeta®), glimepiride (Amaryl®), and
glipizide (Glucotrol®) are examples.
Glinides—also
known as meglitinides—are by increasing insulin production in the pancreas,
these medications lower blood glucose levels. Randin®'s repaglinide and
Starlix®'s nateglinide are two examples.
Biguanides: The liver produces less glucose as a
result of these drugs. It also slows down the process by which carbohydrates
become sugar and makes insulin work better in the body. An example is Metformin
(Glucophage®).
Anti-alpha-glucosidase
drugs: By slowing
down the breakdown of carbohydrates and reducing glucose absorption in the
small intestine, these medications lower blood glucose levels. Precose®'s
acarbose is one example.
Thiazolidinediones: By allowing more glucose to enter
muscles, fat, and the liver, these medications improve the way insulin works in
the body. Pioglitazone (Actos®) and rosiglitazone (Avandia®) are two examples.
GLP-1
analogs, which are also known as incretin mimetics or glucagon-like peptide-1
receptor agonists, are the following: These medications delay the stomach's
emptying of food, reduce liver glucose release after meals, and increase
insulin release. Byetta® exenatide, Victoza® liraglutide, Tanzeum® albiglutide,
Rybelsus® semaglutide, and Trulicity® dulaglutide are all examples.
Dipeptidyl
peptidase-4 inhibitors, also known as DPP-4 inhibitors: These medications
assist your pancreas in producing more insulin after meals. Additionally, they
reduce the amount of glucose produced by the liver. Alogliptin (Nesina®),
sitagliptin (Januvia®), saxagliptin (Onglyza®), and linagliptin (Tradjenta®)
are, among others, examples.
Substances
that block SGLT2, also known as sodium-glucose cotransporter 2 inhibitors:
Utilizing your kidneys, these medications enable you to eliminate glucose from
your body through urine. Canagliflozin (Invokana®), dapagliflozin (Farxiga®),
and empagliflozin (Jardiance®) are a few examples.
Sequestrants
of bile acid: Cholesterol and blood sugar levels are reduced by these drugs.
Colestipol (Colestid®), cholestyramine (Questran®), and colesevelam (Welchol®)
are all examples.
Agonist of
dopamine: The amount of glucose released by the liver is reduced by this
medication. Bromocriptine (Cyclocet®) is one example.
For optimal
blood glucose management, many oral diabetes medications can be combined with
insulin. Some of the above medications are available as a pill that combines
two medications. Other medications, such as the GLP-1 agonists semaglutide
(Ozempic®) and lixisenatide (Adlyxin®), can be injected.
Always take
your medication exactly as prescribed by your doctor. With them, discuss your
specific inquiries and concerns.
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